BDBM359682 N-[(1-Aminoisoquinolin-6-yl)methyl]-5-({6-[2-(hydroxymethyl)pyrrolidin-1-yl]pyridin-3-yl}methyl)pyridine-3-carboxamide::US10221161, Example 67::US11242333, Example 67

SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccc(nc4)N4CCCC4CO)c3)ccc12

InChI Key InChIKey=CDKBTMZPQXYCQA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 359682   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359682(US10221161, Example 67 | N-[(1-Aminoisoquinolin-6-...)
Affinity DataIC50: 73.3nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359682(US10221161, Example 67 | N-[(1-Aminoisoquinolin-6-...)
Affinity DataIC50: 5.15E+3nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359682(US10221161, Example 67 | N-[(1-Aminoisoquinolin-6-...)
Affinity DataIC50: 5.15E+3nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359682(US10221161, Example 67 | N-[(1-Aminoisoquinolin-6-...)
Affinity DataIC50: 73.3nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent