BDBM359673 N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[6-(2-methylpyrrolidin-1-yl)pyridin-3-yl]methyl}pyridine-3-carboxamide::US10221161, Example 58::US11242333, Example 58

SMILES CC1CCCN1c1ccc(Cc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)cn1

InChI Key InChIKey=HCKCTEYBXXLMKG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 359673   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359673(US10221161, Example 58 | N-[(1-Aminoisoquinolin-6-...)
Affinity DataIC50: 153nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359673(US10221161, Example 58 | N-[(1-Aminoisoquinolin-6-...)
Affinity DataIC50: 6.52E+3nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359673(US10221161, Example 58 | N-[(1-Aminoisoquinolin-6-...)
Affinity DataIC50: 6.52E+3nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359673(US10221161, Example 58 | N-[(1-Aminoisoquinolin-6-...)
Affinity DataIC50: 153nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent