BDBM359653 N-[(1-Aminoisoquinolin-6-yl)methyl]-5-[(4-methyl-2,3-dihydro-1,4-benzoxazin-7-yl)methyl]pyridine-3-carboxamide::US10221161, Example 38::US11242333, Example 38

SMILES CN1CCOc2cc(Cc3cncc(c3)C(=O)NCc3ccc4c(N)nccc4c3)ccc12

InChI Key InChIKey=JXTLOXNAUILARA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 359653   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359653(N-[(1-Aminoisoquinolin-6-yl)methyl]-5-[(4-methyl-2...)
Affinity DataIC50: 107nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
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TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359653(N-[(1-Aminoisoquinolin-6-yl)methyl]-5-[(4-methyl-2...)
Affinity DataIC50: 8.60E+3nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359653(N-[(1-Aminoisoquinolin-6-yl)methyl]-5-[(4-methyl-2...)
Affinity DataIC50: 8.60E+3nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359653(N-[(1-Aminoisoquinolin-6-yl)methyl]-5-[(4-methyl-2...)
Affinity DataIC50: 107nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent