BDBM359629 N-[(1-Aminoisoquinolin-6-yl)methyl]-1-({4-[(4-methylpyrazol-1-yl)methyl]phenyl}methyl)-6-oxopyridine-3-carboxamide::US10221161, Example 15::US11242333, Example 15

SMILES Cc1cnn(Cc2ccc(Cn3cc(ccc3=O)C(=O)NCc3ccc4c(N)nccc4c3)cc2)c1

InChI Key InChIKey=JRVPVSFGNJKYLB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 359629   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359629(N-[(1-Aminoisoquinolin-6-yl)methyl]-1-({4-[(4-meth...)
Affinity DataIC50: 159nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359629(N-[(1-Aminoisoquinolin-6-yl)methyl]-1-({4-[(4-meth...)
Affinity DataIC50: 1.76E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359629(N-[(1-Aminoisoquinolin-6-yl)methyl]-1-({4-[(4-meth...)
Affinity DataIC50: 159nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359629(N-[(1-Aminoisoquinolin-6-yl)methyl]-1-({4-[(4-meth...)
Affinity DataIC50: 1.76E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent