BDBM359618 N-[(1-Aminoisoquinolin-6-yl)methyl]-6-oxo-1-({4-[(2-oxopyridin-1-yl)methyl]phenyl}methyl)pyridine-3-carboxamide::US10221161, Example 5::US11242333, Example 5

SMILES Nc1nccc2cc(CNC(=O)c3ccc(=O)n(Cc4ccc(Cn5ccccc5=O)cc4)c3)ccc12

InChI Key InChIKey=UJFXLGBMZVPDMP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 359618   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359618(N-[(1-Aminoisoquinolin-6-yl)methyl]-6-oxo-1-({4-[(...)
Affinity DataIC50: 24.7nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359618(N-[(1-Aminoisoquinolin-6-yl)methyl]-6-oxo-1-({4-[(...)
Affinity DataIC50: 2.89E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359618(N-[(1-Aminoisoquinolin-6-yl)methyl]-6-oxo-1-({4-[(...)
Affinity DataIC50: 24.7nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359618(N-[(1-Aminoisoquinolin-6-yl)methyl]-6-oxo-1-({4-[(...)
Affinity DataIC50: 2.89E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent