BDBM359616 N-[(1-Aminoisoquinolin-6-yl)methyl]-4-({4-[(4-methylpyrazol-1-yl)methyl]phenyl}methyl)pyridine-2-carboxamide::US10221161, Example 3::US11242333, Example 3

SMILES Cc1cnn(Cc2ccc(Cc3ccnc(c3)C(=O)NCc3ccc4c(N)nccc4c3)cc2)c1

InChI Key InChIKey=DZDSGRZPTVIORQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 359616   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359616(N-[(1-Aminoisoquinolin-6-yl)methyl]-4-({4-[(4-meth...)
Affinity DataIC50: 159nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359616(N-[(1-Aminoisoquinolin-6-yl)methyl]-4-({4-[(4-meth...)
Affinity DataIC50: 4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359616(N-[(1-Aminoisoquinolin-6-yl)methyl]-4-({4-[(4-meth...)
Affinity DataIC50: 159nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359616(N-[(1-Aminoisoquinolin-6-yl)methyl]-4-({4-[(4-meth...)
Affinity DataIC50: 4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent