BDBM359555 (R or S)-4-(6-(((1H- pyrazol-5- yl)methyl)(methyl)car- bamoyl)-1-(2- chloro-6-(1- (trifluoromethyl)cyclo- propyl)benzoyl)- 4,5,6,7-tetrahydro- 1H-indazol-3-yl)-3- fluorobenzoic acid::US10221142, Example 21U

SMILES CN(Cc1ccn[nH]1)C(=O)C1CCc2c(C1)n(nc2-c1ccc(cc1F)C(O)=O)C(=O)c1c(Cl)cccc1C1(CC1)C(F)(F)F

InChI Key InChIKey=JKZJJWNRSFJQQK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 359555   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM359555((R or S)-4-(6-(((1H- pyrazol-5- yl)methyl)(methyl)...)
Affinity DataIC50: 0.900nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent