BDBM359538 4-[(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)cyclo- propyl]phenyl}car- bonyl)-6-(5-oxa-2- azaspiro[3.4]oct-2- ylcarbonyl)-4,5,6,7- tetrahydro-1H- indazol-3-yl]-2- methylbenzoic acid::US10221142, Example 21D

SMILES Cc1cc(ccc1C(O)=O)-c1nn(C(=O)c2c(Cl)cccc2C2(CC2)C(F)(F)F)c2CC(CCc12)C(=O)N1CC2(C1)CCCO2

InChI Key InChIKey=DQXFPCZOZDPZJA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 359538   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM359538(4-[(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)...)
Affinity DataIC50: 1.20nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent