BDBM358864 3-(1-Benzofuran-2-yl)-N-[(2R)-1-hydroxy-3-methylbutan-2-yl]imidazo[1,2-b]-pyridazine-6-carboxamide::US10214545, Example 13

SMILES CC(C)[C@H](CO)NC(=O)c1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key InChIKey=HQISLAYJOPDUTK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 358864   

TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM358864(3-(1-Benzofuran-2-yl)-N-[(2R)-1-hydroxy-3-methylbu...)
Affinity DataIC50: 6.80nMAssay Description:MKNK1-inhibitory activity of compounds of the present invention was quantified employing the MKNK1 TR-FRET assay as described in the following paragr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM358864(3-(1-Benzofuran-2-yl)-N-[(2R)-1-hydroxy-3-methylbu...)
Affinity DataIC50: 12nMAssay Description:MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent