BDBM358861 3-(1-Benzofuran-2-yl)-N-[3-(dimethylamino)propyl]imidazo[1,2-b]pyridazine-6-carboxamide::US10214545, Example 10

SMILES CN(C)CCCNC(=O)c1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key InChIKey=DDJUFZKSGQXYOQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 358861   

TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM358861(3-(1-Benzofuran-2-yl)-N-[3-(dimethylamino)propyl]i...)
Affinity DataIC50: 3.30nMAssay Description:MKNK1-inhibitory activity of compounds of the present invention was quantified employing the MKNK1 TR-FRET assay as described in the following paragr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM358861(3-(1-Benzofuran-2-yl)-N-[3-(dimethylamino)propyl]i...)
Affinity DataIC50: 7.90nMAssay Description:MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent