BDBM358675 1-(5-(4-amino-5-chloropyrrolo[2,1-f] [1,2,4]triazin-7-yl)-2-fluorophenyl)- 3,3-dimethyl-4-(2-(methylsulfonyl) acetyl)piperazin-2-one::US10214537, Example 752

SMILES CC1(C)N(CCN(C1=O)c1cc(ccc1F)-c1cc(Cl)c2c(N)ncnn12)C(=O)CS(C)(=O)=O

InChI Key InChIKey=OLWQTTPBTQVFNJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358675   

LigandPNGBDBM358675(1-(5-(4-amino-5-chloropyrrolo[2,1-f] [1,2,4]triazi...)
Affinity DataIC50: 0.600nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent