BDBM357980 5-(1-(4,4-Difluorocyclohexyl)-1H-pyrazol-5-yl)-7-(3-((dimethylamino)methyl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine::US10214537, Example 48

SMILES CN(C)Cc1cccc(c1)-c1cc(-c2ccnn2C2CCC(F)(F)CC2)c2c(N)ncnn12

InChI Key InChIKey=UHQFQWLHLGRBBU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 357980   

LigandPNGBDBM357980(5-(1-(4,4-Difluorocyclohexyl)-1H-pyrazol-5-yl)-7-(...)
Affinity DataIC50: 6nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM357980(5-(1-(4,4-Difluorocyclohexyl)-1H-pyrazol-5-yl)-7-(...)
Affinity DataIC50: 6nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

LigandPNGBDBM357980(5-(1-(4,4-Difluorocyclohexyl)-1H-pyrazol-5-yl)-7-(...)
Affinity DataIC50: 6nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM357980(5-(1-(4,4-Difluorocyclohexyl)-1H-pyrazol-5-yl)-7-(...)
Affinity DataIC50: 144nMAssay Description:Inhibition of PI3Kdelta in BCR-stimulated human B cells assessed as suppression of CD86 expression after 18 hrs by FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM357980(5-(1-(4,4-Difluorocyclohexyl)-1H-pyrazol-5-yl)-7-(...)
Affinity DataIC50: 144nMAssay Description:Inhibition of PI3Kdelta in BCR-stimulated human B cells assessed as suppression of CD86 expression after 18 hrs by FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed