BDBM357945 3-(4-amino-5-(1-cyclohexyl-1H-pyrazol-5-yl) pyrrolo[2,1-f][1,2,4]triazin-7-yl)benzoic acid::US10214537, Example 13

SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCCCC3)c12)-c1cccc(c1)C(O)=O

InChI Key InChIKey=HXNNCLVSKQYQAP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 357945   

LigandPNGBDBM357945(3-(4-amino-5-(1-cyclohexyl-1H-pyrazol-5-yl) pyrrol...)
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM357945(3-(4-amino-5-(1-cyclohexyl-1H-pyrazol-5-yl) pyrrol...)
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM357945(3-(4-amino-5-(1-cyclohexyl-1H-pyrazol-5-yl) pyrrol...)
Affinity DataIC50: 16nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent