BDBM357914 2-Amino-8-fluoro-7-isopropyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid::US10214536, Compound 272

SMILES CC(C)c1cc2c(cc1F)oc1nc(N)c(cc1c2=O)C(O)=O

InChI Key InChIKey=ZAFOQCLNYNBOQC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 357914   

TargetSerine/threonine-protein kinase TBK1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM357914(US10214536, Compound 272 | 2-Amino-8-fluoro-7-isop...)
Affinity DataIC50: 1.24E+3nMAssay Description:Kinase assays are commonly used for determining the ability of a small molecule to inhibit enzyme activity. By measuring the degree of phosphorylatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM357914(US10214536, Compound 272 | 2-Amino-8-fluoro-7-isop...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM357914(US10214536, Compound 272 | 2-Amino-8-fluoro-7-isop...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM357914(US10214536, Compound 272 | 2-Amino-8-fluoro-7-isop...)
Affinity DataIC50: 398nMAssay Description:Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM357914(US10214536, Compound 272 | 2-Amino-8-fluoro-7-isop...)
Affinity DataIC50: 5.37E+3nMAssay Description:Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed