BDBM357909 2-Amino-8-isopropyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid::US10214536, Compound 258

SMILES CC(C)c1ccc2c(c1)oc1nc(N)c(cc1c2=O)C(O)=O

InChI Key InChIKey=ILCMMGSPXXYUSR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 357909   

TargetSerine/threonine-protein kinase TBK1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM357909(US10214536, Compound 258 | 2-Amino-8-isopropyl-5-o...)
Affinity DataIC50: 410nMAssay Description:Kinase assays are commonly used for determining the ability of a small molecule to inhibit enzyme activity. By measuring the degree of phosphorylatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM357909(US10214536, Compound 258 | 2-Amino-8-isopropyl-5-o...)
Affinity DataIC50: 302nMAssay Description:Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM357909(US10214536, Compound 258 | 2-Amino-8-isopropyl-5-o...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM357909(US10214536, Compound 258 | 2-Amino-8-isopropyl-5-o...)
Affinity DataIC50: 4.68E+3nMAssay Description:Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM357909(US10214536, Compound 258 | 2-Amino-8-isopropyl-5-o...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed