BDBM357894 US10214536, Compound 76

SMILES c1cc2c(cc1C3CCS(=O)(=O)CC3)C(=O)c4cc(c(nc4O2)N)C(=O)O

InChI Key InChIKey=YLXHHSZCWBYDQH-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 357894   

TargetSerine/threonine-protein kinase TBK1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM357894(US10214536, Compound 76)
Affinity DataIC50: 170nMAssay Description:Kinase assays are commonly used for determining the ability of a small molecule to inhibit enzyme activity. By measuring the degree of phosphorylatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM357894(US10214536, Compound 76)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM357894(US10214536, Compound 76)
Affinity DataIC50: 830nMAssay Description:Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)