BDBM357851 2-{[(3R,6S)-6-(hydroxymethyl)- 1-{[2-(2,2,2-trifluoroethoxy) pyridin-3-yl]carbonyl}piperidin- 3-yl]oxy}-3-methoxypyridine- 4-carbonitrile::US10214535, Example 11

SMILES COc1c(O[C@@H]2CC[C@@H](CO)N(C2)C(=O)c2cccnc2OCC(F)(F)F)nccc1C#N

InChI Key InChIKey=IPWFEGWGZNINGW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357851   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357851(2-{[(3R,6S)-6-(hydroxymethyl)- 1-{[2-(2,2,2-triflu...)
Affinity DataIC50: 9nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357851(2-{[(3R,6S)-6-(hydroxymethyl)- 1-{[2-(2,2,2-triflu...)
Affinity DataIC50: 4.08E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent