BDBM357843 2-{[(3R,6S)-6-(hydroxymethyl)- 1-{[2-(2H-1,2,3-triazol-2-yl) phenyl]carbonyl}piperidin-3-yl] oxy}pyridine-4-carbonitrile::US10214535, Example 3

SMILES OC[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Oc1cc(ccn1)C#N

InChI Key InChIKey=DLXDZTQMZFOGJV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357843   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357843(2-{[(3R,6S)-6-(hydroxymethyl)- 1-{[2-(2H-1,2,3-tri...)
Affinity DataIC50: 17nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357843(2-{[(3R,6S)-6-(hydroxymethyl)- 1-{[2-(2H-1,2,3-tri...)
Affinity DataIC50: 1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent