BDBM357772 KM447/(I-36)::US10214530, Example 42

SMILES Cn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3nccs3)c2c(=O)[nH]c1=O

InChI Key InChIKey=PSEZKVLBRSZXOK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357772   

TargetTryptophan 5-hydroxylase 2(Human)
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin

US Patent
LigandPNGBDBM357772(KM447/(I-36) | US10214530, Example 42)
Affinity DataIC50: 900nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin

US Patent
LigandPNGBDBM357772(KM447/(I-36) | US10214530, Example 42)
Affinity DataIC50: 2.52E+4nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent