BDBM357741 MW-01-153/(I-47)::US10214530, Example 53

SMILES CCCn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O

InChI Key InChIKey=CNVVLEOEWMATCW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 357741   

TargetTryptophan 5-hydroxylase 1(Human)
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin

US Patent
LigandPNGBDBM357741(MW-01-153/(I-47) | US10214530, Example 53)
Affinity DataIC50: 760nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin

US Patent
LigandPNGBDBM357741(MW-01-153/(I-47) | US10214530, Example 53)
Affinity DataIC50: 50nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin

US Patent
LigandPNGBDBM357741(MW-01-153/(I-47) | US10214530, Example 53)
Affinity DataIC50: 700nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin

US Patent
LigandPNGBDBM357741(MW-01-153/(I-47) | US10214530, Example 53)
Affinity DataIC50: 43nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed