BDBM357251 (5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl)-1H-pyrazol-4-yl)(6-bromo-1H-indol-2-yl)methanone::US10214515, Example 13

SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccc(Br)cc2[nH]1

InChI Key InChIKey=PAGYYFBXLGVGOO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 357251   

TargetFibroblast growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM357251(US10214515, Example 13 | (5-Amino-1-(2-cyclopropyl...)
Affinity DataIC50: 2.60nMAssay Description:The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM357251(US10214515, Example 13 | (5-Amino-1-(2-cyclopropyl...)
Affinity DataIC50: 5nMAssay Description:The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM357251(US10214515, Example 13 | (5-Amino-1-(2-cyclopropyl...)
Affinity DataIC50: 46nMAssay Description:The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM357251(US10214515, Example 13 | (5-Amino-1-(2-cyclopropyl...)
Affinity DataIC50: 1.74E+3nMAssay Description:The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent