BDBM357246 (5-amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl)-1H-pyrazol-4-yl)(1H-indol-2-yl)methanone::US10214515, Example 1

SMILES Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccccc2[nH]1

InChI Key InChIKey=SSKBZCVOJJPLPP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 357246   

TargetFibroblast growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM357246(US10214515, Example 1 | (5-amino-1-(2-cyclopropyl-...)
Affinity DataIC50: 6.20nMAssay Description:The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM357246(US10214515, Example 1 | (5-amino-1-(2-cyclopropyl-...)
Affinity DataIC50: 15.1nMAssay Description:The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM357246(US10214515, Example 1 | (5-amino-1-(2-cyclopropyl-...)
Affinity DataIC50: 22nMAssay Description:The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM357246(US10214515, Example 1 | (5-amino-1-(2-cyclopropyl-...)
Affinity DataIC50: 1.00E+3nMAssay Description:The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent