BDBM35714 CHEMBL420762::Mozavaptan::N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methyl-benzamide::OPC-31260

SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12

InChI Key InChIKey=WRNXUQJJCIZICJ-UHFFFAOYSA-N

Data  15 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 35714   

TargetVasopressin V1a receptor(Human)
Otsuka Pharmaceutical

LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataIC50: 1.40E+3nMpH: 7.4 T: 2°CAssay Description:After reaching confluence in 12-well or 24-well dishes, the cells were washed twice with ice-cold PBS and incubated for 2 hr with [3H]-AVP at 4 deg C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2009
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Human)
Otsuka Pharmaceutical

LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:After reaching confluence in 12-well or 24-well dishes, the cells were washed twice with ice-cold PBS and incubated for 2 hr with [3H]-AVP at 4 deg C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2009
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataIC50: 300nMAssay Description:Inhibitory activity against arginine vasopressin V2 receptor using [3H]AVP as radioligand in rat adrenal medullaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Human)
Otsuka Pharmaceutical

LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataIC50: 500nMAssay Description:Inhibitory activity against human recombinant arginine vasopressin V2 receptor using [3H]AVP as radioligand in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataIC50: 1.40E+3nMAssay Description:Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataKi:  6.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details
PubMed
TargetVasopressin V2 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataKi:  6.36nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetVasopressin V2 receptor(Human)
Otsuka Pharmaceutical

LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataKi:  9.42nMAssay Description:Concentration which inhibit [3H]AVP binding to human Vasopressin V2 receptor coded HeLa cells by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Human)
Otsuka Pharmaceutical

LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataKi:  9.42nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetVasopressin V2 receptor(Human)
Otsuka Pharmaceutical

LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataKi:  9.70nMAssay Description:Binding affinity to vasopressin V2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataKi:  42.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details
PubMed
TargetVasopressin V1a receptor(Human)
Otsuka Pharmaceutical

LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataKi:  150nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetVasopressin V1a receptor(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataKi:  193nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details
PubMed
TargetVasopressin V1a receptor(Human)
Otsuka Pharmaceutical

LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataKi:  195nMAssay Description:Binding affinity to vasopressin V1a receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataKi:  232nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details
PubMed
TargetVasopressin V1a receptor(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataKi:  524nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetOxytocin receptor(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataKi:  660nMAssay Description:Binding affinity to oxytocin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetOxytocin receptor(Rat)
Yamanouchi Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataKi:  1.55E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details
PubMed
TargetVasopressin V1b receptor(Human)
Second Tokushima Institute of New Drug Research

Curated by PDSP Ki Database
LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetVasopressin V1b receptor(Rat)
Yamanouchi Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM35714(N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]a...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details
PubMed