BDBM357031 (Z)-5-(5-Chloro-2-(1H-tetrazol-1-yl)phenyl)-2-(25-fluoro-4-oxo-11h-3-aza -1(4,2)-imidazola-2(1,2)-benzenacyclononaphane-9-yl)pyridine 1-oxide::US10214512, Example 11-a

SMILES [O-][n+]1cc(ccc1C1CCCCC(=O)Nc2ccc(F)cc2-c2c[nH]c1n2)-c1cc(Cl)ccc1-n1cnnn1

InChI Key InChIKey=MKAAOSLIXYNBND-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357031   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357031((Z)-5-(5-Chloro-2-(1H-tetrazol-1-yl)phenyl)-2-(25-...)
Affinity DataKi:  0.220nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetKallikrein-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357031((Z)-5-(5-Chloro-2-(1H-tetrazol-1-yl)phenyl)-2-(25-...)
Affinity DataKi:  2.12nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent