BDBM356330 US10604535, Example 89B::US9815850, Compound 89B::US9896458, No. 89B

SMILES Fc1cc(F)c2NC(=O)[C@@H](NC(=O)c3nnc(Cc4ccccc4)o3)[C@H]3C[C@H]3c2c1

InChI Key InChIKey=WTKHWLYILLVLFG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 356330   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Denali Therapeutics

US Patent
LigandPNGBDBM356330(US9815850, Compound 89B | US9896458, No. 89B | US1...)
Affinity DataIC50: 500nMAssay Description:Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Denali Therapeutics

US Patent
LigandPNGBDBM356330(US9815850, Compound 89B | US9896458, No. 89B | US1...)
Affinity DataIC50: 500nMAssay Description:Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Denali Therapeutics

US Patent
LigandPNGBDBM356330(US9815850, Compound 89B | US9896458, No. 89B | US1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2020
Entry Details
US Patent