BDBM3563 CHEMBL447230::N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine::PD153035 Analog 63

SMILES COc1cc2ncnc(N(C)c3cccc(Br)c3)c2cc1OC

InChI Key InChIKey=IPWGDOZPSOZFOD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 3563   

TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3563(N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin...)
Affinity DataIC50: 152nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3563(N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM3563(N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human VEGFR-2-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed