BDBM356284 US10604535, Example 55::US9815850, Compound 55::US9896458, No. 55

SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccccn3)cc2F)C1=O

InChI Key InChIKey=GLRMEMTWEQACJX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 356284   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Denali Therapeutics

US Patent
LigandPNGBDBM356284(US9815850, Compound 55 | US9896458, No. 55 | US106...)
Affinity DataIC50: 500nMAssay Description:Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Denali Therapeutics

US Patent
LigandPNGBDBM356284(US9815850, Compound 55 | US9896458, No. 55 | US106...)
Affinity DataIC50: 500nMAssay Description:Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Denali Therapeutics

US Patent
LigandPNGBDBM356284(US9815850, Compound 55 | US9896458, No. 55 | US106...)
Affinity DataIC50: 1.00E+3nMAssay Description:Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2020
Entry Details
Go to US Patent