BDBM355928 1-(4-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-yl)-3-(2- chloro-7- cyclopropylpyrazolo [1,5-a]pyrimidin-6- yl)urea::US10442808, Example 52::US9815842, Example 52

SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CC3)n2n1

InChI Key InChIKey=MHTDDROMURWUNV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 355928   

LigandPNGBDBM355928(US9815842, Example 52 | 1-(4-chloro-6-(2H- 1,2,3-t...)
Affinity DataIC50: 0.00500nMAssay Description:IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
Go to US Patent

LigandPNGBDBM355928(US9815842, Example 52 | 1-(4-chloro-6-(2H- 1,2,3-t...)
Affinity DataIC50: 0.00500nMAssay Description:The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

LigandPNGBDBM355928(US9815842, Example 52 | 1-(4-chloro-6-(2H- 1,2,3-t...)
Affinity DataIC50: 5nMAssay Description:Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg^Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM355928(US9815842, Example 52 | 1-(4-chloro-6-(2H- 1,2,3-t...)
Affinity DataIC50: 60nMAssay Description:Inhibition of MALT1 in PMA-stimulated human Jurkat T cells assessed as reduction in IL2 level pretreated for 30 mins followed by PMA-stimulation meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM355928(US9815842, Example 52 | 1-(4-chloro-6-(2H- 1,2,3-t...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MALT1 in human whole blood assessed as reduction in PMA//anti-CD28 antibody-induced IL2 level pre-incubated for 1 hrs before stimulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed