BDBM355894 1-(5-chloro-6- methoxypyridin-3- yl)-3-(2-chloro-7- isopropylpyrazolo[1, 5-a]pyrimidin-6- yl)urea::US10442808, Example 18::US9815842, Example 18

SMILES COc1ncc(NC(=O)Nc2cnc3cc(Cl)nn3c2C(C)C)cc1Cl

InChI Key InChIKey=UJQDOHWUFHHMEA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355894   

LigandPNGBDBM355894(US9815842, Example 18 | 1-(5-chloro-6- methoxypyri...)
Affinity DataIC50: 0.00300nMAssay Description:IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
Go to US Patent

LigandPNGBDBM355894(US9815842, Example 18 | 1-(5-chloro-6- methoxypyri...)
Affinity DataIC50: 0.00300nMAssay Description:The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent