BDBM355379 N-[(1R)-1-{3-fluoro-4- [(trifluoromethyl)sulfanyl]phenyl}- 2-methylpropyl]-2-(4- methoxybenzyl)-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US9815796, Example 470

SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@H](C(C)C)c2ccc(SC(F)(F)F)c(F)c2)cc1

InChI Key InChIKey=BOQIQTNSNAMLHS-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355379   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355379(US9815796, Example 470 | N-[(1R)-1-{3-fluoro-4- [(...)
Affinity DataKi:  1.20nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355379(US9815796, Example 470 | N-[(1R)-1-{3-fluoro-4- [(...)
Affinity DataKi:  1.30nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent