BDBM355171 2-cyclopropyl-N-{(1R)-2,2-dimethyl- 1-[4-(trifluoromethyl)phenyl]propyl}- 6-oxo-1,6-dihydropyrimidine-4- carboxamide::US9815796, Example 262

SMILES CC(C)(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)C1CC1)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=UWLISBFQIFTCKC-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 355171   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355171(US9815796, Example 262 | 2-cyclopropyl-N-{(1R)-2,2...)
Affinity DataKi:  0.650nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355171(US9815796, Example 262 | 2-cyclopropyl-N-{(1R)-2,2...)
Affinity DataKi:  0.790nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355171(US9815796, Example 262 | 2-cyclopropyl-N-{(1R)-2,2...)
Affinity DataKi:  0.850nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent