BDBM355169 N-[(1R)-1-{3-fluoro-4- [(trifluoromethyl)sulfanyl]phenyl} ethyl]-6-oxo-1,6-dihydro-2,2'- bipyrimidine-4-carboxamide::US9815796, Example 260

SMILES C[C@@H](NC(=O)c1cc(=O)[nH]c(n1)-c1ncccn1)c1ccc(SC(F)(F)F)c(F)c1

InChI Key InChIKey=MYJCMJFUYWPRDY-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 355169   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355169(US9815796, Example 260 | N-[(1R)-1-{3-fluoro-4- [(...)
Affinity DataKi:  1nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355169(US9815796, Example 260 | N-[(1R)-1-{3-fluoro-4- [(...)
Affinity DataKi:  1.80nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355169(US9815796, Example 260 | N-[(1R)-1-{3-fluoro-4- [(...)
Affinity DataKi:  1.80nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent