BDBM354742 Preparation of N,N-dimethyl-5-(5-(3,4,5-trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine ::US10485800, Example 19::US9814704, Example 19

SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]cc(-c3ccc(nc3)N(C)C)c2c1

InChI Key InChIKey=ZLGZKSAISQUZPN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354742   

TargetMitogen-activated protein kinase kinase kinase 11(Human)
The University of Rochester

US Patent
LigandPNGBDBM354742(US9814704, Example 19 | Preparation of N,N-dimethy...)
Affinity DataIC50: 100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
The University of Rochester

US Patent
LigandPNGBDBM354742(US9814704, Example 19 | Preparation of N,N-dimethy...)
Affinity DataIC50: 100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
Go to US Patent