BDBM3547 4-N-(3-bromophenyl)-7-chloroquinazoline-4,6-diamine::CHEMBL63469::PD153035 Analog 47

SMILES Nc1cc2c(Nc3cccc(Br)c3)ncnc2cc1Cl

InChI Key InChIKey=DXPXPVHLPOANFF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 3547   

TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3547(4-N-(3-bromophenyl)-7-chloroquinazoline-4,6-diamin...)
Affinity DataIC50: 6.5nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3547(4-N-(3-bromophenyl)-7-chloroquinazoline-4,6-diamin...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM3547(4-N-(3-bromophenyl)-7-chloroquinazoline-4,6-diamin...)
Affinity DataIC50: 1.19E+4nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed