BDBM354481 2-((2-ethyl-6-(3- morpholino- pvrrolidin-1- yl)imidazo[1,2- b]pyridazin-3- yl)(methyl)amino)- 4-(4- fluorophenyl) thiazole-5- carbonitrile::US9796719, Compound 149

SMILES CCc1nc2ccc(nn2c1N(C)c1nc(c(s1)C#N)-c1ccc(F)cc1)N1CCC(C1)N1CCOCC1

InChI Key InChIKey=FTIDMMBXDJDBCD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 354481   

TargetAutotaxin(Human)
Galapagos

US Patent
LigandPNGBDBM354481(2-((2-ethyl-6-(3- morpholino- pvrrolidin-1- yl)imi...)
Affinity DataIC50: 55nMAssay Description:Compound IC50 values are determined in a fluorescent hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using the fluorogenic autotax...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2019
Entry Details
Go to US Patent