BDBM354342 2-(4-(3-((5-cyano- 4-(4- fluorophenyl) thiazol-2- yl)(methyl)amino)- 2-ethylimidazo[1,2- a]pyrazin-6- yl)piperazin-1-yl)- N-methylacetamide::US9796719, Compound 9

SMILES CCc1nc2cnc(cn2c1N(C)c1nc(c(s1)C#N)-c1ccc(F)cc1)N1CCN(CC(=O)NC)CC1

InChI Key InChIKey=GQXNGSAIGQIXAP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354342   

TargetAutotaxin(Human)
Galapagos

US Patent
LigandPNGBDBM354342(2-(4-(3-((5-cyano- 4-(4- fluorophenyl) thiazol-2- ...)
Affinity DataIC50: 5.05E+3nMAssay Description:Compound IC50 values are determined in a fluorescent hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using the fluorogenic autotax...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2019
Entry Details
Go to US Patent

LigandPNGBDBM354342(2-(4-(3-((5-cyano- 4-(4- fluorophenyl) thiazol-2- ...)
Affinity DataIC50: 55nMAssay Description:Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate.5 μL of a dil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2019
Entry Details
Go to US Patent