BDBM354340 (S)-2-((2-ethyl-6- (4-(2-(3- hydroxypyrrolidin- 1-yl)-2- oxoethyl)piperazin- 1-yl)imidazo[1,2- a]pyrazin-3- yl)(methyl)amino)- 4-(4- fluorophenyl) thiazole-5- carbonitrile::US9796719, Compound 7

SMILES CCc1nc2cnc(cn2c1N(C)c1nc(c(s1)C#N)-c1ccc(F)cc1)N1CCN(CC(=O)N2CC[C@H](O)C2)CC1

InChI Key InChIKey=LMRPAPHNCWWKIX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354340   

TargetAutotaxin(Human)
Galapagos

US Patent
LigandPNGBDBM354340((S)-2-((2-ethyl-6- (4-(2-(3- hydroxypyrrolidin- 1-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compound IC50 values are determined in a fluorescent hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using the fluorogenic autotax...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2019
Entry Details
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LigandPNGBDBM354340((S)-2-((2-ethyl-6- (4-(2-(3- hydroxypyrrolidin- 1-...)
Affinity DataIC50: 55nMAssay Description:Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate.5 μL of a dil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2019
Entry Details
Go to US Patent