BDBM354329 1-(4-((2-((3-cyano-5-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)-naphthalen-1-yl)-3-(1-(3-((dimethylphosphoryl)methyl)phenyl)-3-isopropyl-1H-pyrazol-5-yl)urea::US9796742, Example 57

SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OCCN5CCOCC5)cc(c4)C#N)n3)c3ccccc23)n(n1)-c1cccc(CP(C)(C)=O)c1

InChI Key InChIKey=GYAOYHATHSUFRX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 354329   

TargetMitogen-activated protein kinase 14(Human)
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US Patent
LigandPNGBDBM354329(1-(4-((2-((3-cyano-5-(2-morpholinoethoxy)phenyl)am...)
Affinity DataIC50: 21nMAssay Description:The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM354329(1-(4-((2-((3-cyano-5-(2-morpholinoethoxy)phenyl)am...)
Affinity DataIC50: 9nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
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TargetTyrosine-protein kinase SYK(Human)
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US Patent
LigandPNGBDBM354329(1-(4-((2-((3-cyano-5-(2-morpholinoethoxy)phenyl)am...)
Affinity DataIC50: 7nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
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TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM354329(1-(4-((2-((3-cyano-5-(2-morpholinoethoxy)phenyl)am...)
Affinity DataIC50: 1.25E+3nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3 enzyme isoform (Invitrogen), are evaluated by determining the level of acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent