BDBM354314 1-(1-(3-((Dimethylphosphoryl)methyl)phenyl)-3-isopropyl-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino)pyridin-4-yl)oxy)naphthalen-1-yl)urea::US9796742, Example 42

SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)c3)c3ccccc23)n(n1)-c1cccc(CP(C)(C)=O)c1

InChI Key InChIKey=KVPNQKXHQVOBDL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 354314   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM354314(1-(1-(3-((Dimethylphosphoryl)methyl)phenyl)-3-isop...)
Affinity DataIC50: 47nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
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TargetTyrosine-protein kinase SYK(Human)
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US Patent
LigandPNGBDBM354314(1-(1-(3-((Dimethylphosphoryl)methyl)phenyl)-3-isop...)
Affinity DataIC50: 63nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM354314(1-(1-(3-((Dimethylphosphoryl)methyl)phenyl)-3-isop...)
Affinity DataIC50: 6.98E+3nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3 enzyme isoform (Invitrogen), are evaluated by determining the level of acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent