BDBM354295 1-(3-(tert-Butyl)-1-(3-((dimethylphosphoryl)methyl)phenyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9796742, Example 23

SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)n3)c3ccccc23)n(n1)-c1cccc(CP(C)(C)=O)c1

InChI Key InChIKey=IASAFHQCFSUWMI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 354295   

TargetMitogen-activated protein kinase 14(Human)
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US Patent
LigandPNGBDBM354295(1-(3-(tert-Butyl)-1-(3-((dimethylphosphoryl)methyl...)
Affinity DataIC50: 265nMAssay Description:The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM354295(1-(3-(tert-Butyl)-1-(3-((dimethylphosphoryl)methyl...)
Affinity DataIC50: 40nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
Entry Details
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TargetTyrosine-protein kinase SYK(Human)
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LigandPNGBDBM354295(1-(3-(tert-Butyl)-1-(3-((dimethylphosphoryl)methyl...)
Affinity DataIC50: 97nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
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TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM354295(1-(3-(tert-Butyl)-1-(3-((dimethylphosphoryl)methyl...)
Affinity DataIC50: 1.64E+3nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3 enzyme isoform (Invitrogen), are evaluated by determining the level of acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent