BDBM354294 1-(3-(tert-Butyl)-1-(4-(diethylphosphoryl)phenyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino)-pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9796742, Example 22

SMILES CCP(=O)(CC)c1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C

InChI Key InChIKey=WMVCBNJJXIOYAO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 354294   

TargetMitogen-activated protein kinase 14(Human)
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US Patent
LigandPNGBDBM354294(1-(3-(tert-Butyl)-1-(4-(diethylphosphoryl)phenyl)-...)
Affinity DataIC50: 67nMAssay Description:The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM354294(1-(3-(tert-Butyl)-1-(4-(diethylphosphoryl)phenyl)-...)
Affinity DataIC50: 9nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
Entry Details
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TargetTyrosine-protein kinase SYK(Human)
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US Patent
LigandPNGBDBM354294(1-(3-(tert-Butyl)-1-(4-(diethylphosphoryl)phenyl)-...)
Affinity DataIC50: 200nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
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TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM354294(1-(3-(tert-Butyl)-1-(4-(diethylphosphoryl)phenyl)-...)
Affinity DataIC50: 818nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3 enzyme isoform (Invitrogen), are evaluated by determining the level of acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent