BDBM354293 1-(3-(tert-Butyl)-1-(4-(dimethylphosphoryl)phenyl)-1H-pyrazol-5-yl)-3-(4-((2-((7-methyl-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9796742, Example 21

SMILES Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)P(C)(C)=O)C(C)(C)C)c4ccccc34)n2)cc2cn[nH]c12

InChI Key InChIKey=XUIJEFBUBZVZFL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 354293   

TargetMitogen-activated protein kinase 14(Human)
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US Patent
LigandPNGBDBM354293(1-(3-(tert-Butyl)-1-(4-(dimethylphosphoryl)phenyl)...)
Affinity DataIC50: 44nMAssay Description:The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM354293(1-(3-(tert-Butyl)-1-(4-(dimethylphosphoryl)phenyl)...)
Affinity DataIC50: 1nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
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TargetTyrosine-protein kinase SYK(Human)
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LigandPNGBDBM354293(1-(3-(tert-Butyl)-1-(4-(dimethylphosphoryl)phenyl)...)
Affinity DataIC50: 2nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
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TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM354293(1-(3-(tert-Butyl)-1-(4-(dimethylphosphoryl)phenyl)...)
Affinity DataIC50: 761nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3 enzyme isoform (Invitrogen), are evaluated by determining the level of acti...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
Entry Details
Go to US Patent