BDBM353373 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(methylsulfonyl)cyclohex-3-ene-1-carboxamide::US9796708, Example 605

SMILES COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCC(CC1)C(=O)NS(C)(=O)=O

InChI Key InChIKey=UNBHOJAPGUTPPG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 353373   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM353373(4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50: 80nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 9(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM353373(4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50: 89nMAssay Description:Inhibition of CDK9 (unknown origin) using Ulight-labeled substrate measured after 1.5 hrs by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM353373(4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50: 660nMAssay Description:Inhibition of CDK9 in human A-431 cells assessed as reduction in RNA polymerase2 phosphorylation at C-terminal ser2 residue incubated for 4 hrs by In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed