BDBM35322 aminoisoquinoline, 15

SMILES CNc1cc(ncn1)-c1cccnc1Nc1c(C)ccc2c(Nc3cccc(c3)C#C)nccc12

InChI Key InChIKey=AAAXBDFZRXKRPL-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 35322   

LigandPNGBDBM35322(aminoisoquinoline, 15)
Affinity DataIC50: 18nM EC50:  26nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35322(aminoisoquinoline, 15)
Affinity DataIC50: 450nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35322(aminoisoquinoline, 15)
Affinity DataIC50: 420nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM35322(aminoisoquinoline, 15)
Affinity DataIC50: 210nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM35322(aminoisoquinoline, 15)
Affinity DataIC50: 8.10nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed