BDBM3531 CHEMBL541586::CHEMBL94431::N-(3-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine::PD153035 Analog 30

SMILES COc1cc2ncnc(Nc3cccc(F)c3)c2cc1OC

InChI Key InChIKey=DFWBDVRBHHFDNZ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 3531   

TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3531(CHEMBL541586 | N-(3-fluorophenyl)-6,7-dimethoxyqui...)
Affinity DataIC50: 3.80nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3531(CHEMBL541586 | N-(3-fluorophenyl)-6,7-dimethoxyqui...)
Affinity DataIC50: 90nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3531(CHEMBL541586 | N-(3-fluorophenyl)-6,7-dimethoxyqui...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3531(CHEMBL541586 | N-(3-fluorophenyl)-6,7-dimethoxyqui...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article

TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3531(CHEMBL541586 | N-(3-fluorophenyl)-6,7-dimethoxyqui...)
Affinity DataIC50: 25nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation, 0.05-0.10More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article

TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3531(CHEMBL541586 | N-(3-fluorophenyl)-6,7-dimethoxyqui...)
Affinity DataIC50: 31.9nMAssay Description:Displacement of [125I]4-(3-iodoanilino)-6,7-dimethoxyquinazoline from EGFR tyrosine kinase in human A431 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3531(CHEMBL541586 | N-(3-fluorophenyl)-6,7-dimethoxyqui...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human EGFR tyrosine kinase phosphorylation expressed in mouse BaF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed