BDBM351280 5-Chloro-1-methyl-6-[4-[[2-(1-methylpyrazole-4-carbonyl)-2-azaspiro[3.3]heptan-6-yl]methyl]-1H-pyrazol-3-yl]-3,4-dihydroquinolin-2-one::US9796702, 41

SMILES CN1C(=O)CCc2c(Cl)c(ccc12)-c1n[nH]cc1CC1CC2(C1)CN(C2)C(=O)c1cnn(C)c1

InChI Key InChIKey=PFEXLJYVCIXOLE-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 351280   

TargetCytochrome P450 11B2, mitochondrial(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM351280(US9796702, 41 | 5-Chloro-1-methyl-6-[4-[[2-(1-meth...)
Affinity DataEC50:  0.0380nMAssay Description:The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM351280(US9796702, 41 | 5-Chloro-1-methyl-6-[4-[[2-(1-meth...)
Affinity DataEC50:  7.29nMAssay Description:The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent