BDBM350447 (S)-4-amino-6-((1-(3-chloro-6-(2-hydroxyphenyl)imidazo[1,2-b]pyridazin-7-yl)ethyl)amino)pyrimidine-5-carbonitrile::US10208066, Compound 69::US10611777, Compound 69

SMILES COc1ccccc1-c1nn2c(Cl)cnc2cc1[C@H](C)Nc1ncnc(N)c1C#N

InChI Key InChIKey=WPSIRTUKJQGAMQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 350447   

LigandPNGBDBM350447(US10208066, Compound 69 | (S)-4-amino-6-((1-(3-chl...)
Affinity DataIC50: 1nMAssay Description:Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

LigandPNGBDBM350447(US10208066, Compound 69 | (S)-4-amino-6-((1-(3-chl...)
Affinity DataIC50: 23nMAssay Description:Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM350447(US10208066, Compound 69 | (S)-4-amino-6-((1-(3-chl...)
Affinity DataIC50: 133nMAssay Description:Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

LigandPNGBDBM350447(US10208066, Compound 69 | (S)-4-amino-6-((1-(3-chl...)
Affinity DataIC50: 1nMAssay Description:PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

LigandPNGBDBM350447(US10208066, Compound 69 | (S)-4-amino-6-((1-(3-chl...)
Affinity DataIC50: 23nMAssay Description:PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM350447(US10208066, Compound 69 | (S)-4-amino-6-((1-(3-chl...)
Affinity DataIC50: 133nMAssay Description:PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent