BDBM350404 (S)-N4-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)-5-(2H-tetrazol-5-yl)pyrimidine-4,6-diamine::US10208066, Compound 21

SMILES C[C@H](Nc1ncnc(N)c1-c1nn[nH]n1)c1cc2ncc(Cl)n2nc1-c1ccccc1

InChI Key InChIKey=QRMOVIQTJVHSBS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 350404   

LigandPNGBDBM350404(US10208066, Compound 21 | (S)-N4-(1-(3-chloro-6-ph...)
Affinity DataIC50: 6nMAssay Description:Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM350404(US10208066, Compound 21 | (S)-N4-(1-(3-chloro-6-ph...)
Affinity DataIC50: 424nMAssay Description:Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM350404(US10208066, Compound 21 | (S)-N4-(1-(3-chloro-6-ph...)
Affinity DataIC50: 500nMAssay Description:Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent