BDBM350345 (S)-3-(1-((1-acryloylpyrrolidin-3-yl)amino)-8-methoxyisoquinolin-3-yl)-1H-1,2,4-triazol-5(4H)-one::US10307414, Example 29::US9801872, Example 29

SMILES COc1cccc2cc(nc(N[C@H]3CCN(C3)C(=O)C=C)c12)-c1n[nH]c(=O)[nH]1

InChI Key InChIKey=FLDYREMAARAHTJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 350345   

TargetTyrosine-protein kinase BTK(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM350345(US9801872, Example 29 | (S)-3-(1-((1-acryloylpyrro...)
Affinity DataIC50: 2.51nMAssay Description:The inhibitory properties of compounds relative to BTK is determined using a black 384-well-plate format in a buffer which contains 50 mM Hepes, 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM350345(US9801872, Example 29 | (S)-3-(1-((1-acryloylpyrro...)
Affinity DataIC50: 2.51nMAssay Description:The inhibitory properties of compounds relative to BTK is determined using a black 384-well-plate format in a buffer which contains 50 mM Hepes, 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent