BDBM350335 3-(1-(((3R,4S)-1-acryloyl-4-methylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-1H-1,2,4-triazol-5(4H)-one and 3-(1-(((3S,4R)-1-acryloyl-4-methylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-1H-1,2,4-triazol-5(4H)-one (mixture of enantiomers)::US10307414, Example 21::US9801872, Example 19::US9801872, Example 21

SMILES C[C@@H]1CN(C[C@H]1Oc1nc(cc2ccccc12)-c1n[nH]c(=O)[nH]1)C(=O)C=C

InChI Key InChIKey=QINYPBHHGRXHJN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 350335   

TargetTyrosine-protein kinase BTK(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM350335(3-(1-(((3R,4S)-1-acryloyl-4-methylpyrrolidin-3-yl)...)
Affinity DataIC50: 6.31nMAssay Description:The inhibitory properties of compounds relative to BTK is determined using a black 384-well-plate format in a buffer which contains 50 mM Hepes, 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM350335(3-(1-(((3R,4S)-1-acryloyl-4-methylpyrrolidin-3-yl)...)
Affinity DataIC50: 126nMAssay Description:The inhibitory properties of compounds relative to BTK is determined using a black 384-well-plate format in a buffer which contains 50 mM Hepes, 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM350335(3-(1-(((3R,4S)-1-acryloyl-4-methylpyrrolidin-3-yl)...)
Affinity DataIC50: 6.31nMAssay Description:The inhibitory properties of compounds relative to BTK is determined using a black 384-well-plate format in a buffer which contains 50 mM Hepes, 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM350335(3-(1-(((3R,4S)-1-acryloyl-4-methylpyrrolidin-3-yl)...)
Affinity DataIC50: 126nMAssay Description:The inhibitory properties of compounds relative to BTK is determined using a black 384-well-plate format in a buffer which contains 50 mM Hepes, 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent